Salinomycin


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Uses of Salinomycin

In medical terms, salinomycin is considered a polyether antibiotic that has been shown to be effective in destroying cancer stem cells in research settings on mice. Salinomycin is made by a strain of streptomyces albus. Streptomyces is a form of bacteria, usually found in soil but sometimes on plants and animals, and is a source for several antibiotics. Salinomycin has shown to be an antimicrobial agent when used against gram positive bacteria and even certain types of fungi. It has not been shown to work against gram negative bacteria or yeast. It has also been effective in destroying a variety of parasites.

One of the interesting aspects of possibly using salinomycin for cancer treatment is that it's an antibiotic while most cancer drugs currently being use are chemotherapeutic agents. Antibiotics are naturally occurring substances that originate from microorganisms. Chemotherapeutic drugs are synthesized chemically.

Salinomycin is usually a white, yellowish powder with a slight odor. It is soluble in a variety of substances, but almost never soluble in water. After salinomycin is produced the components of the drug stay stable and it is easily mixed into feed for animals.

The drug is generally defined as a polyether potassium antibiotic which can change cellular function and metabolism. It affects sodium and potassium at the cellular level and is chemically classified as an Ionophore. It is solid in its physical state and should be stored at -20 C. It is recommended not to freeze salinomycin in this form.

There have been some concerns regarding the production costs for salinomycin. Costly organic solvents are used in the production of this compound. Proper disposal of waste is required when manufacturing salinomycin. The entire process can be quite expensive.

 

 

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